Beckman's Biogamma Radioimmuno Analyzer was introduced in 1973. Radioimmunoassay (RIA) is a technique for measuring the antigen concentration. Known quantities of radioactive (labeled or “hot”) antigens and antibodies are mixed, then non-radioactive (unlabeled or “cold”) antigens are added at varying concentrations; the labeled and unlabeled antigens compete to bind to the antibodies. The bound and unbound antigens are separated, and the radioactivity of the unbound samples determines the concentration.
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Ayer Jorgensen Macdonald, and Beckman Instruments. “Your Finger and Our Button. The Simplest Way to Count for RIA.,” 1976. Beckman Historical Collection, Box 49, Folder 36. Science History Institute. Philadelphia. https://digital.sciencehistory.org/works/dz010q391.
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