Herbert Eleuterio was born in 1927 in New Bedford, Massachusetts. His parents had emigrated from the Azores, and he spoke no English until he began first grade. His interest in science was sparked by a middle-school biology teacher, and he decided to pursue chemistry after a customer on his paper route gave him a book on organic chemistry. He attended Tufts University, where he was positively influenced by his calculus teacher. He nearly went to graduate school for math, but the dim employment prospects for mathematicians led him to choose chemistry instead. Eleuterio received his PhD from Michigan State, and married shortly after. He spent a year as a post-doc at Ohio State, then took a job at DuPont in Wilmington, Delaware. He was assigned polymer work even though he had no formal polymer background, and he was immediately very successful. His work there included propylene polymerization, olefin catalysis, olefin metathesis, and fluoro polymers, especially high-performance lubricants such as hexafluoropropylene oxide [HFPO]. Eleuterio also became interested in the theory and practice of knowledge creation and knowledge management through his work in exploratory chemistry at DuPont. He spent much of his later career discussing his concept of “degrees of freedom” and its relationship to scientific creativity. He was also a major proponent of creative teamwork in the laboratory. During his tenure with the Atomic Energy Division, which functioned mostly in South Carolina, he helped to create the Ruth Patrick Science Education Center at the University of South Carolina in Aiken. Eleuterio’s final project at DuPont was globalizing corporate R&D. After his retirement from DuPont in 1992, he began teaching part of every year at the National University of Singapore in the engineering and business programs. He also started the Process Analysis and Optimization Enterprise, which evolved into the Center for Process Engineering, in order to build links between industry and academia in Singapore. Eleuterio concludes the interview with a discussion of his family.