Francis O. Rice discusses his life and career in this interview, which begins with mention of his early days in England, his studies at Princeton, and his teaching at New York University. Rice describes his teaching, research, and administrative activities at the Johns Hopkins University and the Catholic University of America. Of central concern is his theory of free radicals. Mrs. Katherine Rice adds to the interview by discussing her husband's professional activities and remembering several of his closest colleagues. The interview concludes with an appraisal of the place of science in Catholic universities and an explanation of the Laidler-ADX controversy of the mid 1950's.