Manson Benedict begins the interview with a discussion of his family background, including the highlights of his father's career in chemistry. He recalls how his early enthusiasm for chemistry was promoted both by his father's work and his summer jobs with Calumet and Hecla Copper Company. He then tells of his dissatisfaction with his Cornell University education, his year at National Aniline, and his decision to enroll at the University of Chicago to obtain a broader liberal education during which he explored economics and socialism. After a colorful description of a summer's work on a fruit farm in Washington state, Benedict describes his enrollment in a graduate physical chemistry program at MIT. He then discusses his National Research Fellowship at Harvard and his decision to work at Kellogg, where he developed the Benedict-Webb-Rubin equation. He describes his significant role in the Manhattan Project, and touches on his subsequent appointment to the Atomic Energy Commission. He concludes the interview with his return to MIT to develop a nuclear engineering curriculum, the accomplishment of which he is most proud.