Oral history interview with Makoto Kuro-o

Oral history interview with Makoto Kuro-o

  • 2006-Mar-06 – 2006-Mar-08
Photograph of Makoto Kuro-o

Makoto Kuro-o grew up in Tokyo, the younger of two children. His father was an engineer, providing air conditioning systems for large structures like the Tokyo train stations. His mother went to college but did not work after she married. At an early age Kuro-o decided he liked science. He attended the local elementary and junior high schools, but a national high school. His high school chemistry and physics teachers were enthusiastic about their subjects and helpful to Kuro-o. At this point he contemplated becoming a doctor; he talks about the higher education system in Japan, his experience getting into medical school, his parents' expectations. He entered medical school at University of Tokyo. Because his father had a heart attack during Kuro-o's second year in medical school, Kuro-o became interested in cardiology and describes his first basic laboratory experience. He did his PhD while spending at least half of his time seeing patients. He met Ryozo Nagai and joined his lab at Tokyo University. Here he discusses his funding; Nagai's research interests; publishing articles; and his postdoctoral work in genetics at the National Institute of Neuroscience of Japan on the age-suppressor gene in mice. During his last year of internship Kuro-o met and married his wife. Kuro-o then accepted a position at the University of Texas Southwestern Medical Center. He talks about his move to the United States; setting up his laboratory; funding in general and specifically the impact of the Pew Scholars Program in the Biomedical Sciences on his work; his lab management style; his teaching responsibilities; and his research on the age-suppressor gene. Next Kuro-o discusses a little more of his research on the age-suppressor gene, his current research on the anti-aging protein and renal disease, and practical applications of his research. Kuro-o then moves on to talk about his future research on the functions of the Klotho protein and about his collaborations, tenure at University of Texas Southwestern Medical Center, his administrative duties, his role in the lab, the running of his laboratory, the process of writing journal articles, and patents. He also describes a typical work day. The interview concludes with Kuro-o's comments on collaborations in science, serendipity in his work, gender and ethnic issues in science, his first impressions of the United States, and a comparison of science in Japan and the United States.

Property Value
Place of interview
  • 83 pages
  • 4 h 32 m 33 s
Rights Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Rights holder
  • Science History Institute
Credit line
  • Courtesy of Science History Institute
Digitization funder
  • Audio synchronization made possible through the generous funding of the National Historical Publications and Records Commission.

Physical location

Oral history number 0615

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Interviewee biographical information

  • January 07, 1960
  • Tochigi, Japan


Year Institution Degree Discipline
1985 Tōkyō Daigaku MD
1991 Tōkyō Daigaku PhD

Professional Experience

Tokyo University Hospital

  • 1985 to 1986 Intern

Tōkyō-to Yōikuin. Byōin

  • 1986 to 1987 Intern
  • 1987 to 1988 Resident in Internal Medicine (Cardiology)

Tōkyō Daigaku

  • 1988 to 1991 Clinical Fellow, the 3rd Department of Internal Medicine

National Institute of Neuroscience (NCNP)

  • 1991 to 1994 Postdoctoral Fellow, Division of Molecular Genetics
  • 1994 to 1998 Domestic Research Fellow, Division of Molecular Genetics

University of Texas Southwestern Medical Center at Dallas

  • 1998 to 2006 Assistant Professor of Pathology
  • 1998 to 2006 Southwestern Medical Foundation Scholar in Biomedical Research
  • 2006 Associate Professor of Pathology


Year(s) Award
1992 Young Investigator's Award, Japanese Circulation Society
1997 Irvine H. Page Arteriosclerosis Research Awards for Young Investigators(Finalist), American Heart Association
1998 Erwin von Bälz Preis, Boehringer Ingelheim
1999 President's Research Council Distinguished Young Researcher Award,UT Southwestern
1999 to 2003 Pew Scholar in the Biomedical Sciences
2000 Ornish Award in Alzheimer's Disease Research, UT Southwestern

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The published version of the transcript may diverge from the interview audio due to edits to the transcript made by staff of the Center for Oral History, often at the request of the interviewee, during the transcript review process.

Complete Interview Audio File Web-quality download

7 Separate Interview Segments Archival-quality downloads