Harland G. Wood begins the interview with a brief discussion of his role in the restructuring of Western Reserve University's medical curriculum. He then reflects on his childhood and education, recalling that his former Latin teacher (then, his high school principal) first sparked his interest in chemistry. He chronicles his career in chemistry and molecular biology from his college years at Macalester through his extensive laboratory research at Iowa State College, where he first developed his concept of the fixation of carbon dioxide by bacteria; the University of Minnesota, where he continued this research; various other temporary positions; and finally, his current work at Case Western Reserve University. Throughout the interview, in addition to discussing research and the influence of various colleagues and associates, he often focuses on the numerous advancements that have occurred during his lifetime and their impact (both positive and negative) on the way laboratory research is conducted. He concludes with his thoughts on the future of science, stressing the importance of continued enthusiasm and motivation in scientists of all ages.