Digital Collections

Bruce Merrifield's peptide synthesizer

  • Before 2006

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Transcript

00:00:00 Do you want me to say anything?

00:00:08 Yeah, unfortunately I don't have a microphone, but if you speak loudly, you should be able, you should pick it up.

00:00:17 So this is the synthesizer that John Stewart, Nils Jernberg, and I built about 35 years ago.

00:00:27 Is this the very first one or is this the second?

00:00:30 This is probably about the third one that was built.

00:00:34 Recently, I put it in two new cabinets, but outside of that, it's all the same as the original.

00:00:43 So we have the electromechanical device over here to serve as a programmer.

00:00:50 And over there, all the liquid handling part of it, the reaction vessel, the shaker, and pumps, and reagent blast, and so on.

00:01:02 So otherwise, this is the same as it was when we first built it.

00:01:07 Where's the original one?

00:01:10 The original one, as far as I can figure out, is the one out in the lab that has been somewhat dismantled.

00:01:18 I don't have it together yet.

00:01:21 The second one is the one we sent down to the Smithsonian.

00:01:27 And it's just on exhibit down there for a while now, probably in dead storage.

00:01:34 And actually, I misspoke. I think John Stewart had the second one.

00:01:39 So that other one would be the third one.

00:01:42 This would be number four.

00:01:46 But they were all built to the same specifications.

00:01:51 The selector valves over here for the amino acids and the solvents were machined by Niels Jernberg, who was a real good machinist.

00:02:02 They're getting ready now to take this down to position in the museum downstairs.

00:02:09 So I'll go over and help them.

00:02:12 Hello, gentlemen.

00:02:42 Okay, that should be all right.

00:02:45 I'll have the camera on.

00:02:48 I'll go over with you, and then when we come back, we'll go to the auditorium.

00:02:55 How far do they have to go, from the B floor to the top?

00:02:59 I go down to B and out to that floor.

00:03:03 Whatever way you want.

00:03:05 You go to B and then go across there.

00:03:08 Otherwise, you have to stair.

00:03:12 You know where the driveway is?

00:03:14 The top of the driveway is on that.

00:03:16 I'm going to need my sandals.

00:03:18 It's going to be hot.

00:03:19 No, it's not.

00:03:20 It's 60.

00:03:21 It's got like two down there.

00:03:25 And that water's going to make it even warmer.

00:03:28 Come on, this is great.

00:03:35 Yeah, I'll get it out.

00:03:39 I'll hold it for you.

00:03:46 You may have to carry it.